Complex 7n2m
Legend
Pocket colors by molecule type
RNA
Protein
DNA
These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).
System information
| Experimental technique | X-ray |
| Experimental resolution | 2.90 |
| System mass | 114.82 kDa |
| Deposition year | 2021 |
| Molecule type | RNA/DNA/Protein |
| # RNA entities | 1 |
| Organism | Homo |
| RCSB PDB Entry | 7n2m |
| Reference | Baranovskiy Andrey G., Babayeva Nigar D., Lisova Alisa E., Morstadt Lucia M., Tahirov Tahir H.. 2022. Structural and functional insight into mismatch extension by human DNA polymerase α Proceedings of the National Academy of Sciences |
Pockets List
Legend
Cell colors for SiteScore and D Score:
Favourable
Intermediate
Unfavourable
Not available
| Score | Threshold | Meaning |
|---|---|---|
| SiteScore | < 0.8 | Non-drug binding site |
| SiteScore | 0.8 – 1.0 | Potential drug binding site |
| SiteScore | > 1.0 | Promising binding site |
| D Score | < 0.83 | Undruggable |
| D Score | 0.83 – 0.98 | Difficult |
| D Score | > 0.98 | Druggable |
Tick a pocket below to highlight it in the 3D structure above.
| Compound | DCP |
| Residue | . / 1301 |
| Chain | D / A |
| Non-redundant | True |
| Interacting RNA chains | B/B |
| RNA environment detailled | DNA, protein, ion |
| RNA environment global | RNA/DNA/Protein |
| RNA family chains | B/B: unknown |
| RNA family global | unknown |
| Volume | 590.30 Å3 |
| Hydrophobicity | 0.321 |
| Hydrophilicity | 1.468 |
| Buriedness | 0.819 |
| Don/acc character | 0.736 |
| SiteScore | 1.081 |
| D Score | 0.953 |
| Kd | — |