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Harnessing RIBOnucleic acid - Small molecules Structures

RNA-SM complexes

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1215 RNA-SM complexes found
Structure of complex 9q6t

9q6t

Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with tiamulin and protein Y at 2.65A resolution

SM: ARG ARG MUL MUL

Structure of complex 9psi

9psi

In situ structure of the human mitoribosome in the A-P-E state from TACO1-knockout cells

SM: NAD SPM SPM

Structure of complex 9psm

9psm

In situ structure of the human mitoribosome in the A/P-P/E state

SM: NAD SPM SPM

Structure of complex 9pyz

9pyz

SARS-CoV-2 core polymerase complex bound to RNA, araUMP, and UTP

SM: UTP

Structure of complex 9q3q

9q3q

Cryo-EM structure of translating Escherichia coli 70S ribosome bound to mRNA, P-site QKF-peptidyl-tRNAPhe, glycyl-tRNAGly in A/T conformation, EF-Tu-GDP, and bottromycin at 2.01A resolution

SM: MQH

Structure of complex 9q3r

9q3r

Cryo-EM structure of the Escherichia coli 70S ribosome bound to mRNA, P-site fMet-tRNAfMet, glycyl-tRNAGly in A/T conformation, EF-Tu-GDPCP, and bottromycin at 1.99A resolution

SM: MQH

Structure of complex 9q6p

9q6p

Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with pleuromutilin and protein Y at 2.70A resolution

SM: A1CQ9 ARG ARG

Structure of complex 9q6q

9q6q

Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with pleuromutilin-18 triazole derivative and protein Y at 2.90A resolution

SM: A1CRE A1CRE ARG ARG

Structure of complex 9q6r

9q6r

Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with pleuromutilin-27 triazole derivative and protein Y at 2.85A resolution

SM: A1CQ7 A1CQ7 ARG ARG

Structure of complex 9q6u

9q6u

Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with tiamulin-26 triazole derivative and protein Y at 2.80A resolution

SM: A1CRD A1CRD ARG ARG

Structure of complex 9q6v

9q6v

Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with tiamulin-31 triazole derivative and protein Y at 2.85A resolution

SM: A1CQ5 A1CQ5 ARG

Structure of complex 9qeg

9qeg

Cryo-EM structure of the 70S ribosome of a MLSb sensitive S. aureus strain "KES34" in complex with solithromycin

SM: EM1

Structure of complex 9qeh

9qeh

Cryo-EM structure of the A2085-methylated 50S ribosome of a MLSb resistant S. aureus strain "MNY196" in complex with solithromycin

SM: EM1

Structure of complex 9qqa

9qqa

Ternary complex of translating ribosome, NAC and NMT1

SM: SPM SPM SPM

Structure of complex 9qqb

9qqb

Quaternary complex of a translating ribosome, NAC, NMT1, and NatA

SM: SPM SPM SPM

Structure of complex 9qqq

9qqq

Cryo-EM structure of SKM-70S ribosomal stalled complex in the major state (vacant A-site, canon)

SM: A1JA7

Structure of complex 9qsj

9qsj

Cryo-EM structure of SKM-70S ribosomal stalled complex in the A-tRNA positioned (Body open) state.

SM: A1JAI

Structure of complex 9rbf

9rbf

Structure of a stalled E. coli 70S RNC-NuoK-86 in complex with the membrane protein insertase SecYEG-YidC

SM: SPM

Structure of complex 9rja

9rja

Manikomycin bound to the Escherichia coli 70S ribosome

SM: PAR

Structure of complex 9ror

9ror

Assembly intermediate of human mitochondrial ribosome small subunit bound to METTL15 and RBFA (Outward conformation) (State M3)

SM: NAD SPM

Structure of complex 9rot

9rot

Assembly intermediate of human mitochondrial ribosome small subunit bound to METTL15, RBFA, and mtIF2 (State M2.1)

SM: NAD SPM

Structure of complex 9sdf

9sdf

Structure at 1.9 A resolution of Thermus thermophilus tyrosyl-tRNA synthetase bound to wild-type modified tRNA(Tyr), tyrosine and AMP

SM: 1PE

Structure of complex 9sfq

9sfq

Structure at 1.9 A resolution of Thermus thermophilus tyrosyl-tRNA synthetase bound to wild-type tRNATyr(GUC).

SM: 1PE 1PE

Structure of complex 9rov

9rov

Assembly intermediate of human mitochondrial ribosome small subunit bound to METTL15 and RBFA (Inward conformation) (State M2)

SM: NAD SPM

Structure of complex 9rpf

9rpf

Assembly intermediate of human mitochondrial ribosome small subunit bound to METTL15 and mS37 (State M4)

SM: NAD

Structure of complex 9rpv

9rpv

Structure of the ZAK-bound human disome

SM: ANM

Structure of complex 9rtu

9rtu

Structure of the 70S-EF-G(P610L)-GDP-Pi ribosome complex with tRNAs in hybrid state 1 (H1-EF-G(P610L)-GDP-Pi)

SM: AM2 AM2 AM2 GDP

Structure of complex 9rtv

9rtv

Structure of the 70S-EF-G(P610L)-GDP-Pi ribosome complex with tRNAs in hybrid state 2 (H2-EF-G(P610L)-GDP-Pi)

SM: AM2 AM2 AM2 GDP

Structure of complex 9ru6

9ru6

Human mitoribosome bound to TACO1 (Translational activator of COX1), mRNA, A/A-, P/P- and (partial) E/E-tRNAs

SM: NAD

Structure of complex 9ru7

9ru7

WT-HEK 80S ribosome bound to Kozak mRNA (WT-Kozak)

SM: HYG

Structure of complex 9ru8

9ru8

WT-HEK 80S ribosome bound to TISU mRNA (WT-TISU)

SM: HYG

Structure of complex 9ru9

9ru9

RPS26dC HEK mutant 80S ribosome bound to Kozak mRNA (RPS26dC-Kozak)

SM: ANM HYG

Structure of complex 9ruc

9ruc

WT-HEK 80S ribosome bound to H2B mRNA (WT-H2B)

SM: HYG

Structure of complex 9s7b

9s7b

Structure of human mitochondrial COX1-translating ribosome nascent chain complex with tRNAs in intermediate state (AP*)

SM: NAD

Structure of complex 9s7c

9s7c

Structure of human mitochondrial COX1-translating ribosome nascent chain complex with tRNAs in initial hybrid state (H1)

SM: NAD

Structure of complex 9s7d

9s7d

Structure of human mitochondrial COX1-translating ribosome nascent chain-OXA1L/MITRAC complex in open state (open COX1-mtRNC-OXA1L/MITRAC)

SM: NAD

Structure of complex 9s7e

9s7e

Structure of human mitochondrial COX1-translating ribosome nascent chain-OXA1L/MITRAC complex in closed state (closed COX1-mtRNC-OXA1L/MITRAC)

SM: NAD

Structure of complex 9slg

9slg

Doxycycline Bound E. coli Ribosome with Rearranged Peptidyl Transferase Centre

SM: DXT

Structure of complex 9spf

9spf

CRYO-EM STRUCTURE OF HUMAN 80S RIBOSOME WITH A/P/E-SITE TRNA AND MRNA CONTAINING N1-METHYLPSEUDOURIDINE

SM: HYG

Structure of complex 9spi

9spi

CRYO-EM STRUCTURE OF HUMAN 80S RIBOSOME WITH A/P/E-SITE TRNA AND MRNA CONTAINING URIDINE

SM: HYG

Structure of complex 9sro

9sro

Cryo-EM structure of SKM-70S ribosomal stalled complex in the rotated state with hybrid tRNAs

SM: A1JAI

Structure of complex 9sum

9sum

CryoEM structure of Candida auris 80S ribosome in complex with Cycloheximide and Geneticin G418

SM: 3HE GET GET GET GET GET GET GET GET GET GET GET GET GET GET GET GET GET GET GET GET GET GET GET GET GET GET GET GET GET GET GET GET GET GET GET GET GET GET GET GET GET GET GET GET GET GET GET GET GET GET GET GET GET GET GET GET GET

Structure of complex 9sx2

9sx2

30S Doxycycline Bound E. coli Ribosome

SM: DXT

Structure of complex 9t5x

9t5x

Structure of a stalled E. coli 70S RNC-NuoK-70 in complex with the membrane protein insertase SecYEG-YidC

SM: SPM

Structure of complex 9t61

9t61

Doxycycline Bound C. burnetii 30S Ribosome

SM: DXT

Structure of complex 9t6h

9t6h

Cryo-EM structure of the 70S ribosome from Francisella tularensis bound to antibiotics chloramphenicol and gentamicin

SM: CLM LLL LLL LLL LLL LLL LLL LLL LLL LLL

Structure of complex 9t7t

9t7t

CryoEM structure of Candida auris 80S ribosome in complex with Blasticidin S

SM: BLS

Structure of complex 9tey

9tey

DalDro bound to the terminating Escherichia coli 70S ribosome

SM: SPM

Structure of complex 9tez

9tez

DalDroS bound to the Escherichia coli 50S ribosomal subunit

SM: SPM

Structure of complex 9ti8

9ti8

Staphylococcus aureus 50S ribosome in complex with RRF, EF-G and fusidic acid (50S-RRF-EF-G-FA)

SM: FUA GDP

Structure of complex 9ti9

9ti9

Staphylococcus aureus 70S ribosome in complex with RRF, EF-G and fusidic acid (70S-RRF-EF-G-FA)

SM: FUA GDP

Structure of complex 9tjv

9tjv

Ternary complex of E. coli leucyl-tRNA synthetase mutant W177A, tRNA(leu) and the leucyl adenylate analog LeuAMS in the aminoacyl transfer state

SM: LSS LSS

Structure of complex 9tjw

9tjw

Ternary complex of E. coli leucyl-tRNA synthetase mutant R178A, tRNA(leu) and the leucyl adenylate analog LeuAMS in the aminoacyl transfer state

SM: LSS LSS

Structure of complex 9tmi

9tmi

E. coli 70S ribosome with A- and P-site tRNA

SM: SCM

Structure of complex 9tnl

9tnl

E. coli 70S ribosome with A/P- and P/E-site tRNA

SM: SCM

Structure of complex 9tqa

9tqa

E. coli 70S ribosome, trapped conformational ground state of SSU-h44 apical loop, with A- and P-site tRNA

SM: SCM

Structure of complex 9tz5

9tz5

Triple Stack Doxycycline Bound 50S Subunit of the Coxiella burnetii Ribosome

SM: DXT DXT DXT

Structure of complex 9tze

9tze

70S Coxiella burnetii Ribosome with Doxycycline and HPFcold

SM: DXT DXT DXT

Structure of complex 9uht

9uht

SARS-CoV-2 E-RTC in complex with RNA-nsp9 and GMPPNP

SM: GNP

Structure of complex 9uwh

9uwh

human mitoribosome trapped by retapamulin

SM: G34 NAD