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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 9ps7

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 3.08
System mass 3157.69 kDa
Deposition year 2025
Molecule type RNA/Protein
# RNA entities 1
Organism Homo
RCSB PDB Entry 9ps7
Reference Wang Shuhui, Brischigliaro Michele, Zhang Yuekang, Wu Chunxiang, Zheng Wei, Barrientos Antoni, Xiong Yong. 2026. Structural basis of TACO1-mediated efficient mitochondrial translation Nature Communications
Equivalence Class NR_all_93855.32
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound NAD
Residue . / 1701
Chain AK / AA
Non-redundant True
Interacting RNA chains CC/AA
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains CC/AA: rRNA
RNA family global rRNA
Volume 919.24 Å3
Hydrophobicity 0.124
Hydrophilicity 1.596
Buriedness 0.817
Don/acc character 0.734
SiteScore 1.080
D Score 0.910
Kd

Compound SPM
Residue . / 1702
Chain BK / AA
Non-redundant True
Interacting RNA chains CC/AA
RNA environment detailled ion
RNA environment global RNA
RNA family chains CC/AA: rRNA
RNA family global rRNA
Volume 942.56 Å3
Hydrophobicity 0.224
Hydrophilicity 1.203
Buriedness 0.810
Don/acc character 3.742
SiteScore 1.225
D Score 1.034
Kd

Compound SPM
Residue . / 1779
Chain AN / AA
Non-redundant True
Interacting RNA chains CC/AA
RNA environment detailled RNA-only
RNA environment global RNA
RNA family chains CC/AA: rRNA
RNA family global rRNA
Volume 209.92 Å3
Hydrophobicity 0.090
Hydrophilicity 1.156
Buriedness 0.770
Don/acc character 3.617
SiteScore 0.642
D Score 0.484
Kd