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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 9qqb

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 3.43
System mass 4090.61 kDa
Deposition year 2025
Molecule type RNA/Protein
# RNA entities 1
Organism Oryctolagus
RCSB PDB Entry 9qqb
Reference Gamerdinger Martin, Echeverria Blanca, Lentzsch Alfred M., Burg Nicolas, Fan Ziyi, Jaskolowski Mateusz, Scaiola Alain, Piening Selina, Shan Shu-ou, Ban Nenad, Deuerling Elke. 2025. Mechanism of cotranslational protein N-myristoylation in human cells Molecular Cell
Equivalence Class NR_all_21280.51, NR_all_06650.50
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound SPM
Residue . / 4911
Chain VC / B5
Non-redundant True
Interacting RNA chains A/B5
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains A/B5: rRNA
RNA family global rRNA
Volume 242.84 Å3
Hydrophobicity 0.011
Hydrophilicity 1.442
Buriedness 0.705
Don/acc character 1.718
SiteScore 0.815
D Score 0.650
Kd

Compound SPM
Residue . / 4914
Chain YC / B5
Non-redundant True
Interacting RNA chains A/B5
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains A/B5: rRNA
RNA family global rRNA
Volume -
Hydrophobicity -
Hydrophilicity -
Buriedness -
Don/acc character -
SiteScore -
D Score -
Kd

Compound SPM
Residue . / 1909
Chain VU / A2
Non-redundant True
Interacting RNA chains BB/A2
RNA environment detailled RNA-only
RNA environment global RNA
RNA family chains BB/A2: rRNA
RNA family global rRNA
Volume 596.82 Å3
Hydrophobicity 0.364
Hydrophilicity 1.032
Buriedness 0.797
Don/acc character 2.792
SiteScore 1.218
D Score 1.082
Kd