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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 9t6h

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 2.40
System mass 2142.07 kDa
Deposition year 2025
Molecule type RNA/Protein
# RNA entities 1
Organism Francisella
RCSB PDB Entry 9t6h
Reference Klima Martin, Silhan Jan, Pavlik Pavla, Hercik Kamil, Boura Evzen. 2026. Structure of the hibernating Francisella tularensis ribosome and mechanistic insights into its inhibition by antibiotics Nucleic Acids Research
Equivalence Class NR_all_21436.1, NR_all_64478.1
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound CLM
Residue . / 3019
Chain PF / A
Non-redundant True
Interacting RNA chains A/A
RNA environment detailled RNA-only
RNA environment global RNA
RNA family chains A/A: rRNA
RNA family global rRNA
Volume 509.36 Å3
Hydrophobicity 0.202
Hydrophilicity 1.167
Buriedness 0.702
Don/acc character 1.201
SiteScore 1.153
D Score 0.981
Kd

Compound LLL
Residue . / 2901
Chain BB / A
Non-redundant True
Interacting RNA chains A/A
RNA environment detailled RNA-only
RNA environment global RNA
RNA family chains A/A: rRNA
RNA family global rRNA
Volume 62.08 Å3
Hydrophobicity 0.185
Hydrophilicity 0.760
Buriedness 0.579
Don/acc character 3.423
SiteScore 0.634
D Score 0.411
Kd

Compound LLL
Residue . / 3021
Chain RF / A
Non-redundant True
Interacting RNA chains A/A
RNA environment detailled RNA-only
RNA environment global RNA
RNA family chains A/A: rRNA
RNA family global rRNA
Volume 238.73 Å3
Hydrophobicity 0.084
Hydrophilicity 1.363
Buriedness 0.804
Don/acc character 1.682
SiteScore 0.902
D Score 0.570
Kd

Compound LLL
Residue . / 3022
Chain SF / A
Non-redundant True
Interacting RNA chains A/A
RNA environment detailled RNA-only
RNA environment global RNA
RNA family chains A/A: rRNA
RNA family global rRNA
Volume -
Hydrophobicity -
Hydrophilicity -
Buriedness -
Don/acc character -
SiteScore -
D Score -
Kd

Compound LLL
Residue . / 3023
Chain TF / A
Non-redundant True
Interacting RNA chains A/A
RNA environment detailled RNA-only
RNA environment global RNA
RNA family chains A/A: rRNA
RNA family global rRNA
Volume 197.91 Å3
Hydrophobicity 0.009
Hydrophilicity 0.766
Buriedness 0.520
Don/acc character 2.426
SiteScore 1.083
D Score 1.002
Kd

Compound LLL
Residue . / 3024
Chain UF / A
Non-redundant True
Interacting RNA chains A/A
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains A/A: rRNA
RNA family global rRNA
Volume 251.76 Å3
Hydrophobicity 0.085
Hydrophilicity 1.378
Buriedness 0.768
Don/acc character 2.283
SiteScore 0.722
D Score 0.509
Kd

Compound LLL
Residue . / 1615
Chain OG / a
Non-redundant True
Interacting RNA chains FA/a
RNA environment detailled RNA-only
RNA environment global RNA
RNA family chains FA/a: rRNA
RNA family global rRNA
Volume 108.73 Å3
Hydrophobicity 0.444
Hydrophilicity 0.796
Buriedness 0.589
Don/acc character 2.828
SiteScore 0.758
D Score 0.564
Kd

Compound LLL
Residue . / 1616
Chain PG / a
Non-redundant True
Interacting RNA chains FA/a
RNA environment detailled RNA-only
RNA environment global RNA
RNA family chains FA/a: rRNA
RNA family global rRNA
Volume -
Hydrophobicity -
Hydrophilicity -
Buriedness -
Don/acc character -
SiteScore -
D Score -
Kd

Compound LLL
Residue . / 1617
Chain QG / a
Non-redundant True
Interacting RNA chains FA/a
RNA environment detailled RNA-only
RNA environment global RNA
RNA family chains FA/a: rRNA
RNA family global rRNA
Volume 767.29 Å3
Hydrophobicity 0.180
Hydrophilicity 1.049
Buriedness 0.751
Don/acc character 2.316
SiteScore 1.181
D Score 1.044
Kd

Compound LLL
Residue . / 1618
Chain RG / a
Non-redundant True
Interacting RNA chains FA/a
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains FA/a: rRNA
RNA family global rRNA
Volume 228.10 Å3
Hydrophobicity 0.442
Hydrophilicity 1.198
Buriedness 0.791
Don/acc character 1.642
SiteScore 0.887
D Score 0.607
Kd