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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 9pkd

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 2.42
System mass 3209.72 kDa
Deposition year 2025
Molecule type RNA/Protein
# RNA entities 1
Organism Homo
RCSB PDB Entry 9pkd
Equivalence Class NR_all_65061.63
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound 3HE
Residue . / 5294
Chain PJ / L5
Non-redundant True
Interacting RNA chains B/L5
RNA environment detailled protein, other
RNA environment global RNA/Other
RNA family chains B/L5: rRNA
RNA family global rRNA
Volume -
Hydrophobicity -
Hydrophilicity -
Buriedness -
Don/acc character -
SiteScore -
D Score -
Kd

Compound HMT
Residue . / 5295
Chain QJ / L5
Non-redundant True
Interacting RNA chains B/L5
RNA environment detailled ion
RNA environment global RNA
RNA family chains B/L5: rRNA
RNA family global rRNA
Volume -
Hydrophobicity -
Hydrophilicity -
Buriedness -
Don/acc character -
SiteScore -
D Score -
Kd

Compound SPM
Residue . / 5259
Chain GI / L5
Non-redundant True
Interacting RNA chains B/L5
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains B/L5: rRNA
RNA family global rRNA
Volume -
Hydrophobicity -
Hydrophilicity -
Buriedness -
Don/acc character -
SiteScore -
D Score -
Kd

Compound SPM
Residue . / 5263
Chain KI / L5
Non-redundant True
Interacting RNA chains B/L5
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains B/L5: rRNA
RNA family global rRNA
Volume -
Hydrophobicity -
Hydrophilicity -
Buriedness -
Don/acc character -
SiteScore -
D Score -
Kd

Compound SPM
Residue . / 5264
Chain LI / L5
Non-redundant True
Interacting RNA chains B/L5
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains B/L5: rRNA
RNA family global rRNA
Volume -
Hydrophobicity -
Hydrophilicity -
Buriedness -
Don/acc character -
SiteScore -
D Score -
Kd

Compound SPM
Residue . / 5267
Chain OI / L5
Non-redundant True
Interacting RNA chains B/L5
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains B/L5: rRNA
RNA family global rRNA
Volume -
Hydrophobicity -
Hydrophilicity -
Buriedness -
Don/acc character -
SiteScore -
D Score -
Kd

Compound SPM
Residue . / 5288
Chain JJ / L5
Non-redundant True
Interacting RNA chains B/L5
RNA environment detailled protein, ion, other
RNA environment global RNA/Other
RNA family chains B/L5: rRNA
RNA family global rRNA
Volume -
Hydrophobicity -
Hydrophilicity -
Buriedness -
Don/acc character -
SiteScore -
D Score -
Kd

Compound SPM
Residue . / 5291
Chain MJ / L5
Non-redundant True
Interacting RNA chains B/L5
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains B/L5: rRNA
RNA family global rRNA
Volume -
Hydrophobicity -
Hydrophilicity -
Buriedness -
Don/acc character -
SiteScore -
D Score -
Kd

Compound SPM
Residue . / 5292
Chain NJ / L5
Non-redundant True
Interacting RNA chains B/L5
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains B/L5: rRNA
RNA family global rRNA
Volume -
Hydrophobicity -
Hydrophilicity -
Buriedness -
Don/acc character -
SiteScore -
D Score -
Kd