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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 9psm

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 2.98
System mass 3138.61 kDa
Deposition year 2025
Molecule type RNA/Protein
# RNA entities 1
Organism Homo
RCSB PDB Entry 9psm
Reference Wang Shuhui, Brischigliaro Michele, Zhang Yuekang, Wu Chunxiang, Zheng Wei, Barrientos Antoni, Xiong Yong. 2026. Structural basis of TACO1-mediated efficient mitochondrial translation Nature Communications
Equivalence Class NR_all_93855.32
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound NAD
Residue . / 1701
Chain ZJ / AA
Non-redundant True
Interacting RNA chains AC/AA
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains AC/AA: rRNA
RNA family global rRNA
Volume 595.45 Å3
Hydrophobicity 0.065
Hydrophilicity 1.502
Buriedness 0.702
Don/acc character 0.747
SiteScore 1.003
D Score 0.871
Kd

Compound SPM
Residue . / 1702
Chain AK / AA
Non-redundant True
Interacting RNA chains AC/AA
RNA environment detailled ion
RNA environment global RNA
RNA family chains AC/AA: rRNA
RNA family global rRNA
Volume 889.40 Å3
Hydrophobicity 0.252
Hydrophilicity 1.166
Buriedness 0.808
Don/acc character 3.202
SiteScore 1.223
D Score 1.044
Kd

Compound SPM
Residue . / 1780
Chain AN / AA
Non-redundant True
Interacting RNA chains AC/AA
RNA environment detailled RNA-only
RNA environment global RNA
RNA family chains AC/AA: rRNA
RNA family global rRNA
Volume 453.45 Å3
Hydrophobicity 0.172
Hydrophilicity 1.216
Buriedness 0.790
Don/acc character 4.864
SiteScore 1.079
D Score 0.847
Kd