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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 9rpv

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 2.35
System mass 7974.13 kDa
Deposition year 2025
Molecule type RNA/Protein
# RNA entities 1
Organism Homo
RCSB PDB Entry 9rpv
Reference Huso Vienna L., Niu Shuangshuang, Catipovic Marco A., Saba James A., Denk Timo, Park Eugene, Cheng Jingdong, Berninghausen Otto, Becker Thomas, Green Rachel, Beckmann Roland. 2026. ZAK activation at the collided ribosome Nature
Equivalence Class NR_all_65061.63
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound ANM
Residue . / 5481
Chain JY / M5
Non-redundant True
Interacting RNA chains AB/M5
RNA environment detailled ion
RNA environment global RNA
RNA family chains AB/M5: rRNA
RNA family global rRNA
Volume 651.36 Å3
Hydrophobicity 0.546
Hydrophilicity 1.043
Buriedness 0.770
Don/acc character 1.364
SiteScore 1.198
D Score 1.062
Kd