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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 9spf

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 2.40
System mass 3881.38 kDa
Deposition year 2025
Molecule type RNA/Protein
# RNA entities 1
Organism Homo
RCSB PDB Entry 9spf
Reference Rozman Batsheva, Broennimann Karin, Rajan K. Shanmugha, Nachshon Aharon, Saha Chiranjeet, Arazi Tamar, Mohan Vishnu, Geiger Tamar, Wollner Clayton J., Richner Justin M., Westhof Eric, Yonath Ada, Bashan Anat, Stern-Ginossar Noam. 2026. N1-Methylpseudouridine directly modulates translation dynamics Nature
Equivalence Class NR_all_46995.72, NR_all_49592.1
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound HYG
Residue . / 2021
Chain ZS / S2
Non-redundant False
Interacting RNA chains VA/S2, TA/Mr
RNA environment detailled ion
RNA environment global RNA
RNA family chains TA/Mr: mRNA, VA/S2: rRNA
RNA family global multiple
Volume 226.04 Å3
Hydrophobicity 0.055
Hydrophilicity 1.104
Buriedness 0.632
Don/acc character 1.477
SiteScore 0.709
D Score 0.642
Kd