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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 9prq

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 3.34
System mass 3096.38 kDa
Deposition year 2025
Molecule type RNA/Protein
# RNA entities 1
Organism Homo
RCSB PDB Entry 9prq
Reference Wang Shuhui, Brischigliaro Michele, Zhang Yuekang, Wu Chunxiang, Zheng Wei, Barrientos Antoni, Xiong Yong. 2026. Structural basis of TACO1-mediated efficient mitochondrial translation Nature Communications
Equivalence Class NR_all_93855.32
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound NAD
Residue . / 1701
Chain XJ / AA
Non-redundant True
Interacting RNA chains BC/AA
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains BC/AA: rRNA
RNA family global rRNA
Volume 894.54 Å3
Hydrophobicity 0.151
Hydrophilicity 1.502
Buriedness 0.822
Don/acc character 0.737
SiteScore 1.083
D Score 0.943
Kd

Compound SPM
Residue . / 1702
Chain YJ / AA
Non-redundant True
Interacting RNA chains BC/AA
RNA environment detailled ion
RNA environment global RNA
RNA family chains BC/AA: rRNA
RNA family global rRNA
Volume 882.20 Å3
Hydrophobicity 0.189
Hydrophilicity 1.160
Buriedness 0.808
Don/acc character 3.240
SiteScore 1.224
D Score 1.047
Kd

Compound SPM
Residue . / 1780
Chain YM / AA
Non-redundant True
Interacting RNA chains BC/AA
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains BC/AA: rRNA
RNA family global rRNA
Volume 556.69 Å3
Hydrophobicity 0.190
Hydrophilicity 1.288
Buriedness 0.807
Don/acc character 3.569
SiteScore 1.145
D Score 0.905
Kd