Complex 7tql
Legend
Pocket colors by molecule type
RNA
Protein
DNA
These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).
System information
| Experimental technique | Electron Microscopy |
| Experimental resolution | 3.20 |
| System mass | 1234.82 kDa |
| Deposition year | 2022 |
| Molecule type | RNA/Protein |
| # RNA entities | 1 |
| Organism | Homo |
| RCSB PDB Entry | 7tql |
| Reference | Lapointe Christopher P., Grosely Rosslyn, Sokabe Masaaki, Alvarado Carlos, Wang Jinfan, Montabana Elizabeth, Villa Nancy, Shin Byung-Sik, Dever Thomas E., Fraser Christopher S., Fernández Israel S., Puglisi Joseph D.. 2022. eIF5B and eIF1A reorient initiator tRNA to allow ribosomal subunit joining Nature |
| Equivalence Class |
NR_all_46995.72,
NR_all_83098.14
BGSU version: 4.52 |
Pockets List
Legend
Cell colors for SiteScore and D Score:
Favourable
Intermediate
Unfavourable
Not available
| Score | Threshold | Meaning |
|---|---|---|
| SiteScore | < 0.8 | Non-drug binding site |
| SiteScore | 0.8 – 1.0 | Potential drug binding site |
| SiteScore | > 1.0 | Promising binding site |
| D Score | < 0.83 | Undruggable |
| D Score | 0.83 – 0.98 | Difficult |
| D Score | > 0.98 | Druggable |
Tick a pocket below to highlight it in the 3D structure above.
| Compound | 5GP |
| Residue | . / 101 |
| Chain | NA / 3 |
| Non-redundant | True |
| Interacting RNA chains | C/3, B/2 |
| RNA environment detailled | RNA-only |
| RNA environment global | RNA |
| RNA family chains | B/2: rRNA, C/3: tRNA |
| RNA family global | multiple |
| Volume | 91.92 Å3 |
| Hydrophobicity | 0.083 |
| Hydrophilicity | 0.605 |
| Buriedness | 0.471 |
| Don/acc character | 2.690 |
| SiteScore | 1.067 |
| D Score | 1.006 |
| Kd | — |