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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 8vvq

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 2.70
System mass 3560.76 kDa
Deposition year 2024
Molecule type RNA/Protein
# RNA entities 1
Organism Bos
RCSB PDB Entry 8vvq
Equivalence Class NR_all_06650.50, NR_all_45392.2, NR_all_47611.2, NR_all_44051.2
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound 5GP
Residue . / 101
Chain ZC / UA
Non-redundant True
Interacting RNA chains TA/UA
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains TA/UA: tRNA
RNA family global tRNA
Volume 325.51 Å3
Hydrophobicity 0.616
Hydrophilicity 1.074
Buriedness 0.769
Don/acc character 1.432
SiteScore 0.828
D Score 0.770
Kd

Compound ANM
Residue . / 5275
Chain SJ / WA
Non-redundant True
Interacting RNA chains VA/WA
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains VA/WA: rRNA
RNA family global rRNA
Volume 677.77 Å3
Hydrophobicity 0.423
Hydrophilicity 1.284
Buriedness 0.831
Don/acc character 1.237
SiteScore 1.239
D Score 1.020
Kd