HARIBOSS

Harnessing RIBOnucleic acid - Small molecules Structures

Compound FME

Identifiers

  • Canonical SMILES: 
    CSCC[C@H](NC=O)C(O)=O
  • IUPAC name: 
    N-formyl-L-methionine
  • InChi: 
    InChI=1S/C6H11NO3S/c1-11-3-2-5(6(9)10)7-4-8/h4-5H,2-3H2,1H3,(H,7,8)(H,9,10)/t5-/m0/s1
  • InChiKey: 
    PYUSHNKNPOHWEZ-YFKPBYRVSA-N

Chemistry rules

Lipinski's RO5 Veber Pfizer's 3/75

External links

439750 DB04464

RNA-SM complexes

PDB code Deposition date Reference publication
5afi Jan. 22, 2015 Fischer Niels, Neumann Piotr, Konevega Andrey L., Bock Lars V., Ficner Ralf, Rodnina Marina V., Stark Holger. . Structure of the E. coli ribosome–EF-Tu complex at <3 Å resolution by Cs-corrected cryo-EM Nature
5uyl Feb. 24, 2017 Loveland Anna B., Demo Gabriel, Grigorieff Nikolaus, Korostelev Andrei A.. . Ensemble cryo-EM elucidates the mechanism of translation fidelity Nature
5uym Feb. 24, 2017 Loveland Anna B., Demo Gabriel, Grigorieff Nikolaus, Korostelev Andrei A.. . Ensemble cryo-EM elucidates the mechanism of translation fidelity Nature
5uyp Feb. 24, 2017 Loveland Anna B., Demo Gabriel, Grigorieff Nikolaus, Korostelev Andrei A.. . Ensemble cryo-EM elucidates the mechanism of translation fidelity Nature
5uyq Feb. 24, 2017 Loveland Anna B., Demo Gabriel, Grigorieff Nikolaus, Korostelev Andrei A.. . Ensemble cryo-EM elucidates the mechanism of translation fidelity Nature
5wdt July 6, 2017 Fislage Marcus, Zhang Jingji, Brown Zuben Patrick, Mandava Chandra Sekhar, Sanyal Suparna, Ehrenberg Måns, Frank Joachim. . Cryo-EM shows stages of initial codon selection on the ribosome by aa-tRNA in ternary complex with GTP and the GTPase-deficient EF-TuH84A Nucleic Acids Research
5we4 July 7, 2017 Fislage Marcus, Zhang Jingji, Brown Zuben Patrick, Mandava Chandra Sekhar, Sanyal Suparna, Ehrenberg Måns, Frank Joachim. . Cryo-EM shows stages of initial codon selection on the ribosome by aa-tRNA in ternary complex with GTP and the GTPase-deficient EF-TuH84A Nucleic Acids Research
5we6 July 7, 2017 Fislage Marcus, Zhang Jingji, Brown Zuben Patrick, Mandava Chandra Sekhar, Sanyal Suparna, Ehrenberg Måns, Frank Joachim. . Cryo-EM shows stages of initial codon selection on the ribosome by aa-tRNA in ternary complex with GTP and the GTPase-deficient EF-TuH84A Nucleic Acids Research
5wf0 July 11, 2017 Fislage Marcus, Zhang Jingji, Brown Zuben Patrick, Mandava Chandra Sekhar, Sanyal Suparna, Ehrenberg Måns, Frank Joachim. . Cryo-EM shows stages of initial codon selection on the ribosome by aa-tRNA in ternary complex with GTP and the GTPase-deficient EF-TuH84A Nucleic Acids Research
5wfk July 12, 2017 Fislage Marcus, Zhang Jingji, Brown Zuben Patrick, Mandava Chandra Sekhar, Sanyal Suparna, Ehrenberg Måns, Frank Joachim. . Cryo-EM shows stages of initial codon selection on the ribosome by aa-tRNA in ternary complex with GTP and the GTPase-deficient EF-TuH84A Nucleic Acids Research
5wfs July 12, 2017 Fislage Marcus, Zhang Jingji, Brown Zuben Patrick, Mandava Chandra Sekhar, Sanyal Suparna, Ehrenberg Måns, Frank Joachim. . Cryo-EM shows stages of initial codon selection on the ribosome by aa-tRNA in ternary complex with GTP and the GTPase-deficient EF-TuH84A Nucleic Acids Research
6ofx April 1, 2019 Svidritskiy Egor, Demo Gabriel, Loveland Anna B, Xu Chen, Korostelev Andrei A. . Extensive ribosome and RF2 rearrangements during translation termination eLife
6v39 Nov. 25, 2019 Morgan Christopher E., Huang Wei, Rudin Susan D., Taylor Derek J., Kirby James E., Bonomo Robert A., Yu Edward W.. . Cryo-electron Microscopy Structure of the Acinetobacter baumannii 70S Ribosome and Implications for New Antibiotic Development mBio
8fto Jan. 12, 2023 Nissley Amos J., Kamal Tammam S., Cate Jamie H.D.. . Interactions between terminal ribosomal RNA helices stabilize theE. colilarge ribosomal subunit RNA

Physicochemical filters

Descriptor Lipinski's RO5 Veber Pfizer's 3/75
Compliance
MW 177.05 g/mol
HBA 3
HBD 2
HBA + HBD
AlogP -0.06
TPSA 66.40
RB 6

Radar chart