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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 6v39

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 3.04
System mass 2163.82 kDa
Deposition year 2019
Molecule type RNA/Protein
# RNA entities 1
Organism Acinetobacter
RCSB PDB Entry 6v39
Reference Morgan Christopher E., Huang Wei, Rudin Susan D., Taylor Derek J., Kirby James E., Bonomo Robert A., Yu Edward W.. 2020. Cryo-electron Microscopy Structure of the Acinetobacter baumannii 70S Ribosome and Implications for New Antibiotic Development mBio
Equivalence Class NR_all_96169.5
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound FME
Residue . / 3001
Chain CB / AN1
Non-redundant True
Interacting RNA chains E/AN1
RNA environment detailled RNA-only
RNA environment global RNA
RNA family chains E/AN1: rRNA
RNA family global rRNA
Volume 776.90 Å3
Hydrophobicity 0.410
Hydrophilicity 1.054
Buriedness 0.726
Don/acc character 1.965
SiteScore 1.169
D Score 1.032
Kd