HARIBOSS

Harnessing RIBOnucleic acid - Small molecules Structures

Compound GMP

Identifiers

  • Canonical SMILES: 
    NC1=Nc2n(cnc2C(=O)N1)[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O
  • IUPAC name: 
    guanosine
  • InChi: 
    InChI=1S/C10H13N5O5/c11-10-13-7-4(8(19)14-10)12-2-15(7)9-6(18)5(17)3(1-16)20-9/h2-3,5-6,9,16-18H,1H2,(H3,11,13,14,19)/t3-,5-,6-,9-/m1/s1
  • InChiKey: 
    NYHBQMYGNKIUIF-UUOKFMHZSA-N

Chemistry rules

Lipinski's RO5 Veber Pfizer's 3/75

External links

135398635 CHEMBL375655 DB02857

RNA-SM complexes

PDB code Deposition date Reference publication
3skz June 23, 2011 Pikovskaya Olga, Polonskaia Anna, Patel Dinshaw J, Serganov Alexander. . Structural principles of nucleoside selectivity in a 2′-deoxyguanosine riboswitch Nature Chemical Biology
3skz June 23, 2011 Pikovskaya Olga, Polonskaia Anna, Patel Dinshaw J, Serganov Alexander. . Structural principles of nucleoside selectivity in a 2′-deoxyguanosine riboswitch Nature Chemical Biology
4x4n Dec. 3, 2014 Kuhn Claus-D., Wilusz Jeremy E., Zheng Yuxuan, Beal Peter A., Joshua-Tor Leemor. . On-Enzyme Refolding Permits Small RNA and tRNA Surveillance by the CCA-Adding Enzyme Cell
8khh Aug. 21, 2023 Chen Ke, Liao Wenjian, Wang Jiali, Ren Yangyi, Lu Zhizhong, Peng Xuemei, Wang Jia, Huang Lin. . Crystal structures reveal the distinct features of the 2′-dG-III riboswitch in the purine riboswitch family Nucleic Acids Research
8khh Aug. 21, 2023 Chen Ke, Liao Wenjian, Wang Jiali, Ren Yangyi, Lu Zhizhong, Peng Xuemei, Wang Jia, Huang Lin. . Crystal structures reveal the distinct features of the 2′-dG-III riboswitch in the purine riboswitch family Nucleic Acids Research
9k9h Oct. 26, 2024 Zhang Xiaojing, An Linfeng, Yang Wen, Yi Ran, Liu Ji, Li Shanshan, Zhang Kaiming. . Self-splicing and cyclization mechanisms of the full-length Anabaena pre-tRNA Nature Chemical Biology
9lkf Jan. 16, 2025 Li Hongcheng, Shen Xin, Xu Xiaochen, Tai Xiaoqing, He Mengqi, Zhang Jinzhu, Ren Aiming. . Ligand specificity and adaptability revealed by the first Guanine-II riboswitch tertiary structure Nucleic Acids Research
9lku Jan. 16, 2025 Shen Xin, Li Hongcheng, Xu Xiaochen, Song Qianqian, Tai Xiaoqing, He Mengqi, Ren Aiming. . Structure-based insights into the ligand specificity tuning of 2′-dG-III riboswitch Nucleic Acids Research
9uw0 May 11, 2025 Shen Xin, Li Hongcheng, Xu Xiaochen, Song Qianqian, Tai Xiaoqing, He Mengqi, Ren Aiming. . Structure-based insights into the ligand specificity tuning of 2′-dG-III riboswitch Nucleic Acids Research
9v7n May 28, 2025 Hong Yibao, Liu Jiashu, Zhang Xiaojing, Liu Ji, Li Shanshan, Zhang Kaiming. . Pre-splicing conformation and stepwise circularization of a group I intron in Azoarcus pre-tRNA Nature Communications
9v7o May 28, 2025 Hong Yibao, Liu Jiashu, Zhang Xiaojing, Liu Ji, Li Shanshan, Zhang Kaiming. . Pre-splicing conformation and stepwise circularization of a group I intron in Azoarcus pre-tRNA Nature Communications

Physicochemical filters

Descriptor Lipinski's RO5 Veber Pfizer's 3/75
Compliance
MW 283.24 g/mol
HBA not available
HBD not available
HBA + HBD
AlogP not available
TPSA not available
RB not available

Radar chart