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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 9k9h

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 3.56
System mass 108.47 kDa
Deposition year 2024
Molecule type RNA
# RNA entities 1
Organism Anabaena
RCSB PDB Entry 9k9h
Reference Zhang Xiaojing, An Linfeng, Yang Wen, Yi Ran, Liu Ji, Li Shanshan, Zhang Kaiming. 2026. Self-splicing and cyclization mechanisms of the full-length Anabaena pre-tRNA Nature Chemical Biology
Equivalence Class NR_all_11702.1
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound GMP
Residue . / 404
Chain E / A
Non-redundant True
Interacting RNA chains A/A
RNA environment detailled ion
RNA environment global RNA
RNA family chains A/A: tRNA
RNA family global tRNA
Volume 563.89 Å3
Hydrophobicity 0.151
Hydrophilicity 1.254
Buriedness 0.766
Don/acc character 3.045
SiteScore 1.195
D Score 0.990
Kd