HARIBOSS

Harnessing RIBOnucleic acid - Small molecules Structures

Compound 747

Identifiers

  • Canonical SMILES: 
    CN1C(=O)\C(=C\c2cc(F)c(O)c(F)c2)N=C1\C=N\O
  • IUPAC name: 
    (5Z)-5-[(3,5-difluoro-4-hydroxyphenyl)methylidene]-2-[(E)-(hydroxyimino)methyl]-3-methyl-3,5-dihydro-4H-imidazol-4-one
  • InChi: 
    InChI=1S/C12H9F2N3O3/c1-17-10(5-15-20)16-9(12(17)19)4-6-2-7(13)11(18)8(14)3-6/h2-5,18,20H,1H3/b9-4-,15-5+
  • InChiKey: 
    MZFHSQVSFUWKDU-TUUOAFJKSA-N

Chemistry rules

Lipinski's RO5 Veber Pfizer's 3/75

RNA-SM complexes

PDB code Deposition date Reference publication
5bjo Aug. 21, 2016 Warner Katherine Deigan, Sjekloća Ljiljana, Song Wenjiao, Filonov Grigory S, Jaffrey Samie R, Ferré-D'Amaré Adrian R. . A homodimer interface without base pairs in an RNA mimic of red fluorescent protein Nature Chemical Biology
5bjp Aug. 21, 2016 Warner Katherine Deigan, Sjekloća Ljiljana, Song Wenjiao, Filonov Grigory S, Jaffrey Samie R, Ferré-D'Amaré Adrian R. . A homodimer interface without base pairs in an RNA mimic of red fluorescent protein Nature Chemical Biology
7kvv Nov. 28, 2020 Truong Lynda, Kooshapur Hamed, Dey Sourav Kumar, Li Xing, Tjandra Nico, Jaffrey Samie R., Ferré-D’Amaré Adrian R.. . The fluorescent aptamer Squash extensively repurposes the adenine riboswitch fold Nature Chemical Biology
8eyv Oct. 28, 2022 Passalacqua Luiz F. M., Starich Mary R., Link Katie A., Wu Jiahui, Knutson Jay R., Tjandra Nico, Jaffrey Samie R., Ferré-D’Amaré Adrian R.. . Co-crystal structures of the fluorogenic aptamer Beetroot show that close homology may not predict similar RNA architecture Nature Communications
8eyv Oct. 28, 2022 Passalacqua Luiz F. M., Starich Mary R., Link Katie A., Wu Jiahui, Knutson Jay R., Tjandra Nico, Jaffrey Samie R., Ferré-D’Amaré Adrian R.. . Co-crystal structures of the fluorogenic aptamer Beetroot show that close homology may not predict similar RNA architecture Nature Communications
8f0n Nov. 3, 2022 Passalacqua Luiz F. M., Starich Mary R., Link Katie A., Wu Jiahui, Knutson Jay R., Tjandra Nico, Jaffrey Samie R., Ferré-D’Amaré Adrian R.. . Co-crystal structures of the fluorogenic aptamer Beetroot show that close homology may not predict similar RNA architecture Nature Communications
8f0n Nov. 3, 2022 Passalacqua Luiz F. M., Starich Mary R., Link Katie A., Wu Jiahui, Knutson Jay R., Tjandra Nico, Jaffrey Samie R., Ferré-D’Amaré Adrian R.. . Co-crystal structures of the fluorogenic aptamer Beetroot show that close homology may not predict similar RNA architecture Nature Communications

Physicochemical filters

Descriptor Lipinski's RO5 Veber Pfizer's 3/75
Compliance
MW 281.06 g/mol
HBA 5
HBD 2
HBA + HBD
AlogP 1.34
TPSA 85.49
RB 2

Radar chart