HARIBOSS

Harnessing RIBOnucleic acid - Small molecules Structures

Compound ZVM

Identifiers

  • Canonical SMILES:
    CN1c2ccccc2C(=O)[C@H]3C(=O)N([C@H](N=C13)C4CCC4)c5ccccc5
  • IUPAC name:
    (2S,4aS)-2-cyclobutyl-10-methyl-3-phenyl-2,10-dihydropyrimido[4,5-b]quinoline-4,5(3H,4aH)-dione
  • InChi:
    InChI=1S/C22H21N3O2/c1-24-17-13-6-5-12-16(17)19(26)18-21(24)23-20(14-8-7-9-14)25(22(18)27)15-10-3-2-4-11-15/h2-6,10-14,18,20H,7-9H2,1H3/t18?,20-/m0/s1
  • InChiKey:
    HIWASGKNWCATJA-IJHRGXPZSA-N

Chemistry rules

Lipinski's RO5 Veber Pfizer's 3/75

RNA-SM complexes

PDB code Deposition date Reference publication
8scb April 5, 2023 Coelho João P. L., Yip Matthew C. J., Oltion Keely, Taunton Jack, Shao Sichen. . The eRF1 degrader SRI-41315 acts as a molecular glue at the ribosomal decoding center Nature Chemical Biology

Physicochemical filters

Descriptor Lipinski's RO5 Veber Pfizer's 3/75
Compliance
MW 359.16 g/mol
HBA 4
HBD 0
HBA + HBD
AlogP 3.51
TPSA 52.98
RB 2

Radar chart