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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 9r96

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 3.10
System mass 237.35 kDa
Deposition year 2025
Molecule type RNA/DNA/Protein
# RNA entities 1
Organism N/A
RCSB PDB Entry 9r96
Reference Shen Jiayu, Goovaerts Quinten, Ajjugal Yogeeshwar, De Wijngaert Brent, Das Kalyan, Patel Smita S.. 2025. Human mitochondrial RNA polymerase structures reveal transcription start site and slippage mechanism Molecular Cell

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound GTP
Residue . / 1301
Chain G / A
Non-redundant True
Interacting RNA chains E/R
RNA environment detailled DNA, protein, ion
RNA environment global RNA/DNA/Protein
RNA family chains E/R: RNA/DNA_hybrid
RNA family global RNA/DNA_hybrid
Volume 673.31 Å3
Hydrophobicity 0.563
Hydrophilicity 1.452
Buriedness 0.822
Don/acc character 0.572
SiteScore 1.083
D Score 0.960
Kd