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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 9ey1

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 2.90
System mass 280.43 kDa
Deposition year 2024
Molecule type RNA/Protein
# RNA entities 1
Organism Homo
RCSB PDB Entry 9ey1
Reference Valentín Gesé Genís, Hällberg B Martin. 2024. Structural basis of 3′-tRNA maturation by the human mitochondrial RNase Z complex The EMBO Journal
Equivalence Class NR_all_77785.2
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound GTP
Residue . / 201
Chain I / T
Non-redundant True
Interacting RNA chains F/T
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains F/T: tRNA
RNA family global tRNA
Volume 479.17 Å3
Hydrophobicity 0.220
Hydrophilicity 1.443
Buriedness 0.817
Don/acc character 0.730
SiteScore 1.080
D Score 0.960
Kd