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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 6szv

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 2.50
System mass 285.41 kDa
Deposition year 2019
Molecule type RNA/Protein
# RNA entities 1
Organism Betainfluenzavirus
RCSB PDB Entry 6szv
Reference Wandzik Joanna M., Kouba Tomas, Karuppasamy Manikandan, Pflug Alexander, Drncova Petra, Provaznik Jan, Azevedo Nayara, Cusack Stephen. 2020. A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase Cell
Equivalence Class NR_all_27410.1
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound 2KH
Residue . / 801
Chain J / B
Non-redundant True
Interacting RNA chains E/R, F/M
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains E/R: unknown, F/M: mRNA
RNA family global mRNA
Volume 648.27 Å3
Hydrophobicity 0.091
Hydrophilicity 1.919
Buriedness 0.844
Don/acc character 0.466
SiteScore 1.097
D Score 0.821
Kd