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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 6oy6

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique X-ray
Experimental resolution 3.10
System mass 441.56 kDa
Deposition year 2019
Molecule type RNA/DNA/Protein
# RNA entities 1
Organism Thermus
RCSB PDB Entry 6oy6
Reference Shin Yeonoh, Hedglin Mark, Murakami Katsuhiko S. 2020. Structural basis of reiterative transcription from the pyrG and pyrBI promoters by bacterial RNA polymerase Nucleic Acids Research

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound GTP
Residue . / 1604
Chain N / D
Non-redundant True
Interacting RNA chains I/I
RNA environment detailled DNA, protein, ion
RNA environment global RNA/DNA/Protein
RNA family chains I/I: unknown
RNA family global unknown
Volume 71.34 Å3
Hydrophobicity 0.000
Hydrophilicity 2.434
Buriedness 0.954
Don/acc character 0.354
SiteScore 0.872
D Score 0.335
Kd