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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 3ja1

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 3.60
System mass 2311.02 kDa
Deposition year 2015
Molecule type RNA/Protein
# RNA entities 1
Organism Escherichia
RCSB PDB Entry 3ja1
Reference Li Wen, Liu Zheng, Koripella Ravi Kiran, Langlois Robert, Sanyal Suparna, Frank Joachim. 2015. Activation of GTP hydrolysis in mRNA-tRNA translocation by elongation factor G Science Advances
Equivalence Class NR_all_83717.187
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound GTP
Residue . / 801
Chain GB / S3
Non-redundant True
Interacting RNA chains Z/LA
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains Z/LA: rRNA
RNA family global rRNA
Volume 653.42 Å3
Hydrophobicity 0.038
Hydrophilicity 1.432
Buriedness 0.744
Don/acc character 0.834
SiteScore 1.031
D Score 0.920
Kd