Compound ZC0

Identifiers

Canonical SMILES:

Fc1cc(N2C[C@H](CNc3ccon3)OC2=O)c(F)c(F)c1N4CCC(=O)C=C4

IUPAC name:

1-{2,3,6-trifluoro-4-[(5S)-5-{[(1,2-oxazol-3-yl)amino]methyl}-2-oxo-1,3-oxazolidin-3-yl]phenyl}-2,3-dihydropyridin-4(1H)-one

InChi:

InChI=1S/C18H15F3N4O4/c19-12-7-13(15(20)16(21)17(12)24-4-1-10(26)2-5-24)25-9-11(29-18(25)27)8-22-14-3-6-28-23-14/h1,3-4,6-7,11H,2,5,8-9H2,(H,22,23)/t11-/m0/s1

InChiKey:
```
SULYVXZZUMRQAX-NSHDSACASA-N
```

SMARTS:

[#9]-[#6]1:[#6]:[#6](-[#7]2-[#6]-[#6@H](-[#6]-[#7]-[#6]3:[#6]:[#6]:[#8]:[#7]:3)-[#8]-[#6]-2=[#8]):[#6](-[#9]):[#6](-[#9]):[#6]:1-[#7]1-[#6]-[#6]-[#6](=[#8])-[#6]=[#6]-1

Chemistry rules

Lipinski's RO5	Veber	Pfizer's 3/75

External links

25184541

CHEMBL3287379 PDB Logo

ZC0

DB12796

RNA-SM complexes

PDB code	Deposition date	Reference publication
6wqn	April 29, 2020	Wright Alexander, Deane-Alder Kieran, Marschall Edward, Bamert Rebecca, Venugopal Hari, Lithgow Trevor, Lupton David W., Belousoff Matthew J.. 2020. Characterization of the Core Ribosomal Binding Region for the Oxazolidone Family of Antibiotics Using Cryo-EM ACS Pharmacology & Translational Science

Physicochemical filters

Descriptor	Lipinski's RO5	Veber	Pfizer's 3/75
MW	≤ 500 g/mol	-	-
AlogP	≤ 5	-	≤ 3
HBA	≤ 10	-	-
HBD	≤ 5	-	-
(HBA + HBD)	-	≤ 12	-
TPSA	-	≤ 140 Å²	≥ 75 Å²
RB	-	≤ 10	-

	Descriptor	Lipinski's RO5	Veber	Pfizer's 3/75
Compliance
MW	408.11 g/mol
HBA	7
HBD	1
HBA + HBD
AlogP	2.82
TPSA	87.91
RB	5

HARIBOSS

Compound ZC0

Identifiers

Chemistry rules

External links

RNA-SM complexes

Physicochemical filters

Radar chart