HARIBOSS

Harnessing RIBOnucleic acid - Small molecules Structures

Compound V5A

Identifiers

  • Canonical SMILES:
    Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[V](O)=O)[C@@H](O)[C@H]3O
  • IUPAC name:
    (adenosinato-kappaO~5'~)(hydroxy)oxovanadium
  • InChi:
    InChI=1S/C10H12N5O4.H2O.O.V/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10;;;/h2-4,6-7,10,17-18H,1H2,(H2,11,12,13);1H2;;/q-1;;;+2/p-1/t4-,6-,7-,10-;;;/m1.../s1
  • InChiKey:
    JVJRKVXEYLCGDR-MSQVLRTGSA-M

Chemistry rules

Lipinski's RO5 Veber Pfizer's 3/75

RNA-SM complexes

PDB code Deposition date Reference publication
4ndg Oct. 26, 2013 Tumbale Percy, Williams Jessica S., Schellenberg Matthew J., Kunkel Thomas A., Williams R. Scott. . Aprataxin resolves adenylated RNA–DNA junctions to maintain genome integrity Nature
4ndg Oct. 26, 2013 Tumbale Percy, Williams Jessica S., Schellenberg Matthew J., Kunkel Thomas A., Williams R. Scott. . Aprataxin resolves adenylated RNA–DNA junctions to maintain genome integrity Nature

Physicochemical filters

Descriptor Lipinski's RO5 Veber Pfizer's 3/75
Compliance
MW 350.03 g/mol
HBA 9
HBD 4
HBA + HBD
AlogP -2.17
TPSA 165.84
RB 4

Radar chart