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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 9z2o

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 2.66
System mass 113.28 kDa
Deposition year 2025
Molecule type RNA/Protein
# RNA entities 1
Organism Homo
RCSB PDB Entry 9z2o
Reference Canepa Jacob, Ruiz-Arroyo Victor M., Schlamowitz Netanya S., Nam Yunsun. 2026. Substrate selectivity of the human RNA m5C methyltransferase NSUN2 Nature
Equivalence Class NR_all_03605.1
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound SAH
Residue . / 801
Chain C / A
Non-redundant True
Interacting RNA chains B/B
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains B/B: tRNA
RNA family global tRNA
Volume 407.48 Å3
Hydrophobicity 0.493
Hydrophilicity 1.214
Buriedness 0.823
Don/acc character 1.265
SiteScore 1.083
D Score 1.038
Kd