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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 9ymu

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 2.70
System mass 522.33 kDa
Deposition year 2025
Molecule type RNA/DNA/Protein
# RNA entities 1
Organism Escherichia
RCSB PDB Entry 9ymu
Reference Mueller Andreas U., Darst Seth A.. 2026. Structural basis for multi-subunit DNA-dependent RNA polymerase catalytic activity Molecular Cell
Equivalence Class NR_all_48777.6
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound CTP
Residue . / 1505
Chain N / J
Non-redundant True
Interacting RNA chains E/R
RNA environment detailled DNA, protein, ion
RNA environment global RNA/DNA/Protein
RNA family chains E/R: unknown
RNA family global unknown
Volume 575.55 Å3
Hydrophobicity 0.518
Hydrophilicity 1.280
Buriedness 0.800
Don/acc character 0.726
SiteScore 1.068
D Score 1.003
Kd