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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 9vma

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 3.46
System mass 722.57 kDa
Deposition year 2025
Molecule type RNA/DNA/Protein
# RNA entities 1
Organism Escherichia
RCSB PDB Entry 9vma
Reference Han Jie, Liu Bin, Tang Jingjing, Zhang Shuqin, Wang Xiaoshen, Li Xuzichao, Zhang Qian, Liu Zhikun, Wang Wanyao, Liu Yingcan, Zhou Ruimin, Yin Hang, Wei Yong, Li Zhuang, Zhang Minjie, Deng Zengqin, Zhang Heng. 2025. Non-coding RNA mediates the defense-associated reverse transcriptase (DRT) anti-phage oligomerization transition The EMBO Journal
Equivalence Class NR_all_73630.1
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound DTP
Residue . / 501
Chain S / A
Non-redundant True
Interacting RNA chains G/G
RNA environment detailled DNA, protein, ion
RNA environment global RNA/DNA/Protein
RNA family chains G/G: unknown
RNA family global unknown
Volume 518.96 Å3
Hydrophobicity 0.324
Hydrophilicity 1.402
Buriedness 0.785
Don/acc character 0.527
SiteScore 1.058
D Score 0.954
Kd