HARIBOSS logo

HARIBOSS

Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 9uwh

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 3.00
System mass 2939.79 kDa
Deposition year 2025
Molecule type RNA/Protein
# RNA entities 1
Organism Homo
RCSB PDB Entry 9uwh
Reference Wakigawa Taisei, Mito Mari, Ando Yushin, Yamashiro Haruna, Tomuro Kotaro, Tani Haruna, Tomizawa Kazuhito, Chujo Takeshi, Nagao Asuteka, Suzuki Takeo, Nureki Osamu, Wei Fan-Yan, Shichino Yuichi, Itoh Yuzuru, Suzuki Tsutomu, Iwasaki Shintaro. 2025. Monitoring the complexity and dynamics of mitochondrial translation Molecular Cell
Equivalence Class NR_all_12763.37, NR_all_93855.32
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound G34
Residue . / 6456
Chain TI / A
Non-redundant True
Interacting RNA chains A/A
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains A/A: rRNA
RNA family global rRNA
Volume 893.86 Å3
Hydrophobicity 0.405
Hydrophilicity 1.039
Buriedness 0.797
Don/acc character 2.429
SiteScore 1.217
D Score 1.080
Kd

Compound NAD
Residue . / 1701
Chain BJ / AA
Non-redundant True
Interacting RNA chains Y/AA
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains Y/AA: rRNA
RNA family global rRNA
Volume 860.24 Å3
Hydrophobicity 0.158
Hydrophilicity 1.446
Buriedness 0.800
Don/acc character 0.738
SiteScore 1.049
D Score 0.925
Kd