HARIBOSS logo

HARIBOSS

Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 9ukt

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 2.77
System mass 461.44 kDa
Deposition year 2025
Molecule type RNA/DNA/Protein
# RNA entities 1
Organism Thermus
RCSB PDB Entry 9ukt
Reference Duan Wenqian, Kaushik Abhishek, Unarta Ilona C., Wu Yue, Liu Mengjie M. J., Weaver Jacob W., Wang Bing, Rice William J., Luciano Daniel J., Belasco Joel G., Huang Xuhui, Nudler Evgeny, Serganov Alexander. 2026. Molecular basis for noncanonical transcription initiation from Np4A alarmones Nature Chemical Biology
Equivalence Class NR_all_66802.1
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound CTP
Residue . / 1601
Chain M / D
Non-redundant True
Interacting RNA chains I/I
RNA environment detailled DNA, protein, ion
RNA environment global RNA/DNA/Protein
RNA family chains I/I: unknown
RNA family global unknown
Volume 473.68 Å3
Hydrophobicity 0.493
Hydrophilicity 1.338
Buriedness 0.817
Don/acc character 0.763
SiteScore 0.942
D Score 0.817
Kd