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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 9tmi

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 2.08
System mass 2200.37 kDa
Deposition year 2025
Molecule type RNA/Protein
# RNA entities 1
Organism Escherichia
RCSB PDB Entry 9tmi
Reference Steinmetzger Christian, Karlsson Hampus, Fontana Carolina, Galindo Riera Natalia, Riad Magdalena, Kosek David, Schlagnitweit Judith, Steiner Emilie, Sandoz Sarah Friebe, Andersson Emma R., Petzold Katja. 2026. Universal 3D Motif dynamics in RNA: The A-minor Switch preprint (openRxiv)
Equivalence Class NR_all_56726.172
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound SCM
Residue . / 1601
Chain MB / A
Non-redundant True
Interacting RNA chains ZA/A
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains ZA/A: rRNA
RNA family global rRNA
Volume 605.40 Å3
Hydrophobicity 0.126
Hydrophilicity 1.453
Buriedness 0.822
Don/acc character 1.305
SiteScore 1.233
D Score 0.960
Kd