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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 9ruc

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 2.50
System mass 3815.60 kDa
Deposition year 2025
Molecule type RNA/Protein
# RNA entities 1
Organism Homo
RCSB PDB Entry 9ruc
Reference Fraticelli Davide, Hiregange Disha Gajanan, Weiss Benjamin, Ogran Ariel, Havkin-Solomon Tal, Roman Irene Martinez, Bashan Anat, Yonath Ada, Dikstein Rivka. 2026. Structural and molecular basis of specialized translation mediated by the ribosome mRNA-binding channel Nature Communications
Equivalence Class NR_all_46995.72
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound HYG
Residue . / 1901
Chain JD / S2
Non-redundant False
Interacting RNA chains XA/mR, UB/S2
RNA environment detailled RNA-only
RNA environment global RNA
RNA family chains UB/S2: rRNA, XA/mR: mRNA
RNA family global multiple
Volume -
Hydrophobicity -
Hydrophilicity -
Buriedness -
Don/acc character -
SiteScore -
D Score -
Kd