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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 9pj9

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 2.50
System mass 2281.58 kDa
Deposition year 2025
Molecule type RNA/Protein
# RNA entities 1
Organism Cutibacterium
RCSB PDB Entry 9pj9
Reference Devarkar Swapnil C., Lomakin Ivan B., Wang Jimin, Grada Ayman, Bunick Christopher G.. 2026. Dual site targeting of the bacterial 70S ribosome by tetracyclines Nature Communications
Equivalence Class NR_all_00194.1, NR_all_86966.1
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound MIY
Residue . / 3344
Chain VM / a
Non-redundant True
Interacting RNA chains DA/a
RNA environment detailled ion
RNA environment global RNA
RNA family chains DA/a: rRNA
RNA family global rRNA
Volume -
Hydrophobicity -
Hydrophilicity -
Buriedness -
Don/acc character -
SiteScore -
D Score -
Kd

Compound MIY
Residue . / 1647
Chain AD / A
Non-redundant True
Interacting RNA chains CA/Y, F/A
RNA environment detailled ion
RNA environment global RNA
RNA family chains F/A: rRNA, CA/Y: mRNA
RNA family global multiple
Volume 186.59 Å3
Hydrophobicity 0.375
Hydrophilicity 0.902
Buriedness 0.724
Don/acc character 2.333
SiteScore 0.953
D Score 0.771
Kd

Compound MIY
Residue . / 3364
Chain PN / a
Non-redundant True
Interacting RNA chains DA/a
RNA environment detailled ion
RNA environment global RNA
RNA family chains DA/a: rRNA
RNA family global rRNA
Volume 705.55 Å3
Hydrophobicity 0.140
Hydrophilicity 1.627
Buriedness 0.737
Don/acc character 0.839
SiteScore 1.176
D Score 0.852
Kd