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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 9pg8

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 3.06
System mass 3138.14 kDa
Deposition year 2025
Molecule type RNA/Protein
# RNA entities 1
Organism Homo
RCSB PDB Entry 9pg8
Reference Wang Shuhui, Brischigliaro Michele, Zhang Yuekang, Wu Chunxiang, Zheng Wei, Barrientos Antoni, Xiong Yong. 2026. Structural basis of TACO1-mediated efficient mitochondrial translation Nature Communications
Equivalence Class NR_all_93855.32
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound NAD
Residue . / 1701
Chain ZJ / AA
Non-redundant True
Interacting RNA chains DC/AA
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains DC/AA: rRNA
RNA family global rRNA
Volume 587.56 Å3
Hydrophobicity 0.109
Hydrophilicity 1.460
Buriedness 0.681
Don/acc character 0.678
SiteScore 0.989
D Score 0.873
Kd

Compound SPM
Residue . / 1702
Chain AK / AA
Non-redundant True
Interacting RNA chains DC/AA
RNA environment detailled ion
RNA environment global RNA
RNA family chains DC/AA: rRNA
RNA family global rRNA
Volume 846.52 Å3
Hydrophobicity 0.141
Hydrophilicity 1.187
Buriedness 0.803
Don/acc character 2.222
SiteScore 1.220
D Score 1.035
Kd

Compound SPM
Residue . / 1782
Chain CN / AA
Non-redundant True
Interacting RNA chains DC/AA
RNA environment detailled other
RNA environment global RNA/Other
RNA family chains DC/AA: rRNA
RNA family global rRNA
Volume 190.02 Å3
Hydrophobicity 0.048
Hydrophilicity 1.400
Buriedness 0.828
Don/acc character 2.239
SiteScore 0.712
D Score 0.450
Kd

Compound SPM
Residue . / 1785
Chain FN / AA
Non-redundant True
Interacting RNA chains DC/AA
RNA environment detailled protein, ion, other
RNA environment global RNA/Other
RNA family chains DC/AA: rRNA
RNA family global rRNA
Volume 869.85 Å3
Hydrophobicity 0.105
Hydrophilicity 1.705
Buriedness 0.818
Don/acc character 1.142
SiteScore 1.230
D Score 0.875
Kd