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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 9pfr

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 3.08
System mass 364.50 kDa
Deposition year 2025
Molecule type RNA/Protein
# RNA entities 1
Organism Orthopneumovirus
RCSB PDB Entry 9pfr
Reference Cao Dongdong, Chen Zhenhang, Gao Yunrong, Roesler Claire, Gooneratne Inesh, Mera Cristopher, Zhuang Lisa, Slack Julia, Nudell-Cook Elijah, Vy Jenny, Berry Jasmine, Royal Maurice, Shaik Masthan, Youngs Ryan, Liang Bo. 2026. Orchestrated and dynamic nucleotide addition cycle during respiratory syncytial virus early-stage elongation Nature Communications
Equivalence Class NR_all_39409.1
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound ZAN
Residue . / 2202
Chain I / A
Non-redundant False
Interacting RNA chains G/T, F/P
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains F/P: unknown, G/T: unknown
RNA family global unknown
Volume 717.90 Å3
Hydrophobicity 0.756
Hydrophilicity 1.155
Buriedness 0.874
Don/acc character 0.578
SiteScore 1.117
D Score 1.088
Kd