HARIBOSS logo

HARIBOSS

Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 9p7y

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 2.75
System mass 3275.42 kDa
Deposition year 2025
Molecule type RNA/Protein
# RNA entities 1
Organism Homo
RCSB PDB Entry 9p7y
Reference Zheng Wei, Zhang Yuekang, Wang Jimin, Wang Shuhui, Chai Pengxin, Bailey Elizabeth J., Zhu Chenghao, Guo Wangbiao, Devarkar Swapnil C., Wu Shenping, Lin Jianfeng, Zhang Kai, Liu Jun, Lomakin Ivan B., Xiong Yong. 2025. Visualizing the translation landscape in human cells at high resolution Nature Communications
Equivalence Class NR_all_65061.63
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound SPM
Residue . / 5259
Chain MJ / L5
Non-redundant True
Interacting RNA chains OA/L5
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains OA/L5: rRNA
RNA family global rRNA
Volume 374.21 Å3
Hydrophobicity 0.449
Hydrophilicity 0.956
Buriedness 0.670
Don/acc character 1.623
SiteScore 1.147
D Score 1.030
Kd

Compound SPM
Residue . / 5263
Chain QJ / L5
Non-redundant True
Interacting RNA chains OA/L5
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains OA/L5: rRNA
RNA family global rRNA
Volume 123.48 Å3
Hydrophobicity 0.163
Hydrophilicity 1.126
Buriedness 0.599
Don/acc character 1.674
SiteScore 0.785
D Score 0.549
Kd

Compound SPM
Residue . / 5264
Chain RJ / L5
Non-redundant True
Interacting RNA chains OA/L5
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains OA/L5: rRNA
RNA family global rRNA
Volume -
Hydrophobicity -
Hydrophilicity -
Buriedness -
Don/acc character -
SiteScore -
D Score -
Kd

Compound SPM
Residue . / 5267
Chain UJ / L5
Non-redundant True
Interacting RNA chains OA/L5
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains OA/L5: rRNA
RNA family global rRNA
Volume 714.13 Å3
Hydrophobicity 0.083
Hydrophilicity 1.994
Buriedness 0.855
Don/acc character 0.963
SiteScore 1.255
D Score 0.803
Kd

Compound SPM
Residue . / 5288
Chain PK / L5
Non-redundant True
Interacting RNA chains OA/L5
RNA environment detailled protein, ion, other
RNA environment global RNA/Other
RNA family chains OA/L5: rRNA
RNA family global rRNA
Volume 707.61 Å3
Hydrophobicity 0.134
Hydrophilicity 1.802
Buriedness 0.838
Don/acc character 0.836
SiteScore 1.094
D Score 0.856
Kd

Compound SPM
Residue . / 5291
Chain SK / L5
Non-redundant True
Interacting RNA chains OA/L5
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains OA/L5: rRNA
RNA family global rRNA
Volume 1373.72 Å3
Hydrophobicity 0.088
Hydrophilicity 1.603
Buriedness 0.822
Don/acc character 1.102
SiteScore 1.083
D Score 0.911
Kd

Compound SPM
Residue . / 5292
Chain TK / L5
Non-redundant True
Interacting RNA chains OA/L5
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains OA/L5: rRNA
RNA family global rRNA
Volume 722.70 Å3
Hydrophobicity 0.176
Hydrophilicity 1.278
Buriedness 0.779
Don/acc character 1.445
SiteScore 1.054
D Score 0.991
Kd