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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 9p7w

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 2.93
System mass 3251.32 kDa
Deposition year 2025
Molecule type RNA/Protein
# RNA entities 1
Organism Homo
RCSB PDB Entry 9p7w
Reference Zheng Wei, Zhang Yuekang, Wang Jimin, Wang Shuhui, Chai Pengxin, Bailey Elizabeth J., Zhu Chenghao, Guo Wangbiao, Devarkar Swapnil C., Wu Shenping, Lin Jianfeng, Zhang Kai, Liu Jun, Lomakin Ivan B., Xiong Yong. 2025. Visualizing the translation landscape in human cells at high resolution Nature Communications
Equivalence Class NR_all_65061.63
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound SPM
Residue . / 5258
Chain KJ / L5
Non-redundant True
Interacting RNA chains NA/L5
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains NA/L5: rRNA
RNA family global rRNA
Volume 348.49 Å3
Hydrophobicity 0.528
Hydrophilicity 1.101
Buriedness 0.728
Don/acc character 1.303
SiteScore 1.170
D Score 1.018
Kd

Compound SPM
Residue . / 5263
Chain PJ / L5
Non-redundant True
Interacting RNA chains NA/L5
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains NA/L5: rRNA
RNA family global rRNA
Volume 97.76 Å3
Hydrophobicity 0.000
Hydrophilicity 1.671
Buriedness 0.624
Don/acc character 2.566
SiteScore 0.782
D Score 0.362
Kd

Compound SPM
Residue . / 5264
Chain QJ / L5
Non-redundant True
Interacting RNA chains NA/L5
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains NA/L5: rRNA
RNA family global rRNA
Volume -
Hydrophobicity -
Hydrophilicity -
Buriedness -
Don/acc character -
SiteScore -
D Score -
Kd

Compound SPM
Residue . / 5267
Chain TJ / L5
Non-redundant True
Interacting RNA chains NA/L5
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains NA/L5: rRNA
RNA family global rRNA
Volume 756.66 Å3
Hydrophobicity 0.123
Hydrophilicity 1.840
Buriedness 0.847
Don/acc character 1.260
SiteScore 1.249
D Score 0.848
Kd

Compound SPM
Residue . / 5288
Chain OK / L5
Non-redundant True
Interacting RNA chains NA/L5
RNA environment detailled protein, ion, other
RNA environment global RNA/Other
RNA family chains NA/L5: rRNA
RNA family global rRNA
Volume 350.89 Å3
Hydrophobicity 0.074
Hydrophilicity 1.982
Buriedness 0.818
Don/acc character 0.835
SiteScore 0.742
D Score 0.351
Kd

Compound SPM
Residue . / 5291
Chain RK / L5
Non-redundant True
Interacting RNA chains NA/L5
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains NA/L5: rRNA
RNA family global rRNA
Volume 1197.07 Å3
Hydrophobicity 0.091
Hydrophilicity 1.613
Buriedness 0.829
Don/acc character 0.933
SiteScore 1.087
D Score 0.911
Kd

Compound SPM
Residue . / 5292
Chain SK / L5
Non-redundant True
Interacting RNA chains NA/L5
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains NA/L5: rRNA
RNA family global rRNA
Volume 626.32 Å3
Hydrophobicity 0.175
Hydrophilicity 1.223
Buriedness 0.783
Don/acc character 1.559
SiteScore 1.057
D Score 1.011
Kd