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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 9p7a

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 2.81
System mass 3868.94 kDa
Deposition year 2025
Molecule type RNA/Protein
# RNA entities 1
Organism Homo
RCSB PDB Entry 9p7a
Reference Zheng Wei, Zhang Yuekang, Wang Jimin, Wang Shuhui, Chai Pengxin, Bailey Elizabeth J., Zhu Chenghao, Guo Wangbiao, Devarkar Swapnil C., Wu Shenping, Lin Jianfeng, Zhang Kai, Liu Jun, Lomakin Ivan B., Xiong Yong. 2025. Visualizing the translation landscape in human cells at high resolution Nature Communications
Equivalence Class NR_all_65061.63
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound SPM
Residue . / 5259
Chain KI / L5
Non-redundant True
Interacting RNA chains C/L5
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains C/L5: rRNA
RNA family global rRNA
Volume 334.43 Å3
Hydrophobicity 0.464
Hydrophilicity 0.956
Buriedness 0.691
Don/acc character 1.500
SiteScore 1.162
D Score 1.043
Kd

Compound SPM
Residue . / 5263
Chain OI / L5
Non-redundant True
Interacting RNA chains C/L5
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains C/L5: rRNA
RNA family global rRNA
Volume 113.88 Å3
Hydrophobicity 0.188
Hydrophilicity 1.251
Buriedness 0.610
Don/acc character 1.398
SiteScore 0.779
D Score 0.498
Kd

Compound SPM
Residue . / 5264
Chain PI / L5
Non-redundant True
Interacting RNA chains C/L5
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains C/L5: rRNA
RNA family global rRNA
Volume -
Hydrophobicity -
Hydrophilicity -
Buriedness -
Don/acc character -
SiteScore -
D Score -
Kd

Compound SPM
Residue . / 5267
Chain SI / L5
Non-redundant True
Interacting RNA chains C/L5
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains C/L5: rRNA
RNA family global rRNA
Volume 742.94 Å3
Hydrophobicity 0.111
Hydrophilicity 1.916
Buriedness 0.853
Don/acc character 0.904
SiteScore 1.103
D Score 0.827
Kd

Compound SPM
Residue . / 5289
Chain OJ / L5
Non-redundant True
Interacting RNA chains C/L5
RNA environment detailled protein, ion, other
RNA environment global RNA/Other
RNA family chains C/L5: rRNA
RNA family global rRNA
Volume 380.04 Å3
Hydrophobicity 0.127
Hydrophilicity 1.810
Buriedness 0.833
Don/acc character 0.819
SiteScore 0.854
D Score 0.547
Kd

Compound SPM
Residue . / 5292
Chain RJ / L5
Non-redundant True
Interacting RNA chains C/L5
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains C/L5: rRNA
RNA family global rRNA
Volume 969.32 Å3
Hydrophobicity 0.100
Hydrophilicity 1.604
Buriedness 0.818
Don/acc character 0.912
SiteScore 1.080
D Score 0.908
Kd

Compound SPM
Residue . / 5294
Chain TJ / L5
Non-redundant True
Interacting RNA chains C/L5
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains C/L5: rRNA
RNA family global rRNA
Volume 650.67 Å3
Hydrophobicity 0.209
Hydrophilicity 1.280
Buriedness 0.786
Don/acc character 1.250
SiteScore 1.059
D Score 0.995
Kd