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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 9p72

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 2.80
System mass 3251.31 kDa
Deposition year 2025
Molecule type RNA/Protein
# RNA entities 1
Organism Homo
RCSB PDB Entry 9p72
Reference Zheng Wei, Zhang Yuekang, Wang Jimin, Wang Shuhui, Chai Pengxin, Bailey Elizabeth J., Zhu Chenghao, Guo Wangbiao, Devarkar Swapnil C., Wu Shenping, Lin Jianfeng, Zhang Kai, Liu Jun, Lomakin Ivan B., Xiong Yong. 2025. Visualizing the translation landscape in human cells at high resolution Nature Communications
Equivalence Class NR_all_65061.63
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound SPM
Residue . / 5259
Chain II / L5
Non-redundant True
Interacting RNA chains C/L5
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains C/L5: rRNA
RNA family global rRNA
Volume 346.43 Å3
Hydrophobicity 0.376
Hydrophilicity 1.079
Buriedness 0.652
Don/acc character 1.282
SiteScore 0.969
D Score 0.979
Kd

Compound SPM
Residue . / 5263
Chain MI / L5
Non-redundant True
Interacting RNA chains C/L5
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains C/L5: rRNA
RNA family global rRNA
Volume 131.03 Å3
Hydrophobicity 0.188
Hydrophilicity 1.092
Buriedness 0.581
Don/acc character 1.455
SiteScore 0.857
D Score 0.658
Kd

Compound SPM
Residue . / 5264
Chain NI / L5
Non-redundant True
Interacting RNA chains C/L5
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains C/L5: rRNA
RNA family global rRNA
Volume -
Hydrophobicity -
Hydrophilicity -
Buriedness -
Don/acc character -
SiteScore -
D Score -
Kd

Compound SPM
Residue . / 5267
Chain QI / L5
Non-redundant True
Interacting RNA chains C/L5
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains C/L5: rRNA
RNA family global rRNA
Volume 777.24 Å3
Hydrophobicity 0.112
Hydrophilicity 1.868
Buriedness 0.848
Don/acc character 1.221
SiteScore 1.100
D Score 0.840
Kd

Compound SPM
Residue . / 5289
Chain MJ / L5
Non-redundant True
Interacting RNA chains C/L5
RNA environment detailled protein, ion, other
RNA environment global RNA/Other
RNA family chains C/L5: rRNA
RNA family global rRNA
Volume 326.88 Å3
Hydrophobicity 0.036
Hydrophilicity 1.700
Buriedness 0.814
Don/acc character 0.777
SiteScore 0.718
D Score 0.413
Kd

Compound SPM
Residue . / 5292
Chain PJ / L5
Non-redundant True
Interacting RNA chains C/L5
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains C/L5: rRNA
RNA family global rRNA
Volume 1094.17 Å3
Hydrophobicity 0.127
Hydrophilicity 1.585
Buriedness 0.813
Don/acc character 1.100
SiteScore 1.077
D Score 0.911
Kd

Compound SPM
Residue . / 5293
Chain QJ / L5
Non-redundant True
Interacting RNA chains C/L5
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains C/L5: rRNA
RNA family global rRNA
Volume 706.58 Å3
Hydrophobicity 0.144
Hydrophilicity 1.331
Buriedness 0.791
Don/acc character 0.984
SiteScore 1.062
D Score 0.981
Kd