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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 9o3k

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique X-ray
Experimental resolution 2.70
System mass 4566.11 kDa
Deposition year 2025
Molecule type RNA/Protein
# RNA entities 1
Organism Thermus
RCSB PDB Entry 9o3k
Reference Syroegin Egor A., Aleksandrova Elena V., Kruglov Artem A., Paranjpe Madhura N., Svetlov Maxim S., Polikanov Yury S.. 2025. Structural insights into context-specific inhibition of bacterial translation by macrolides preprint (bioRxiv)
Equivalence Class NR_all_97519.80
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound ERY
Residue . / 4098
Chain PTA / 1A
Non-redundant True
Interacting RNA chains A/1A
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains A/1A: rRNA
RNA family global rRNA
Volume 189.34 Å3
Hydrophobicity 0.355
Hydrophilicity 0.846
Buriedness 0.610
Don/acc character 2.032
SiteScore 0.968
D Score 0.825
Kd

Compound ERY
Residue . / 3688
Chain ZKC / 2A
Non-redundant True
Interacting RNA chains FB/2A
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains FB/2A: rRNA
RNA family global rRNA
Volume 230.84 Å3
Hydrophobicity 0.328
Hydrophilicity 0.854
Buriedness 0.602
Don/acc character 1.696
SiteScore 0.946
D Score 0.989
Kd