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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 9mna

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 3.77
System mass 266.47 kDa
Deposition year 2024
Molecule type RNA/DNA/Protein
# RNA entities 1
Organism N/A
RCSB PDB Entry 9mna
Reference Herbine Karl, Nayak Ashok R., Zamudio-Ochoa Angelica, Temiakov Dmitry. 2025. Structural basis for promoter recognition and transcription factor binding and release in human mitochondria Molecular Cell

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound ATP
Residue . / 1302
Chain H / E
Non-redundant True
Interacting RNA chains F/R
RNA environment detailled DNA, protein, ion
RNA environment global RNA/DNA/Protein
RNA family chains F/R: synthetic construct
RNA family global synthetic construct
Volume 393.42 Å3
Hydrophobicity 0.525
Hydrophilicity 1.698
Buriedness 0.884
Don/acc character 0.585
SiteScore 1.094
D Score 0.878
Kd