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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 9k6h

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 3.00
System mass 166.11 kDa
Deposition year 2024
Molecule type RNA/DNA/Protein
# RNA entities 1
Organism Trichoplusia
RCSB PDB Entry 9k6h
Reference Jin Wenxing, Yu Cong, Zhang Yan, Cao Changchang, Xia Tianfan, Song Ge, Cai Zhaokui, Xue Yuanchao, Zhu Bing, Xu Rui-Ming. 2025. Mechanism of DNA targeting by human LINE-1 Science
Equivalence Class NR_all_05931.1
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound DTP
Residue . / 1301
Chain F / A
Non-redundant True
Interacting RNA chains E/E
RNA environment detailled DNA, protein, ion
RNA environment global RNA/DNA/Protein
RNA family chains E/E: unknown
RNA family global unknown
Volume 554.63 Å3
Hydrophobicity 0.273
Hydrophilicity 1.617
Buriedness 0.812
Don/acc character 0.493
SiteScore 1.076
D Score 0.900
Kd