Complex 9g23
Legend
Pocket colors by molecule type
RNA
Protein
DNA
These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).
System information
| Experimental technique | Electron Microscopy |
| Experimental resolution | 3.40 |
| System mass | 618.17 kDa |
| Deposition year | 2024 |
| Molecule type | RNA/DNA/Protein |
| # RNA entities | 1 |
| Organism | Saccharomyces |
| RCSB PDB Entry | 9g23 |
| Reference | Santos-Aledo Alicia, Plaza-Pegueroles Adrián, Sanz-Murillo Marta, Ruiz Federico M., Hou Peini, Xu Jun, Gil-Carton David, Wang Dong, Fernández-Tornero Carlos. 2025. Cryo-EM uncovers a sequential mechanism for RNA polymerase I pausing and stalling at abasic DNA lesions Nature Communications |
Pockets List
Legend
Cell colors for SiteScore and D Score:
Favourable
Intermediate
Unfavourable
Not available
| Score | Threshold | Meaning |
|---|---|---|
| SiteScore | < 0.8 | Non-drug binding site |
| SiteScore | 0.8 – 1.0 | Potential drug binding site |
| SiteScore | > 1.0 | Promising binding site |
| D Score | < 0.83 | Undruggable |
| D Score | 0.83 – 0.98 | Difficult |
| D Score | > 0.98 | Druggable |
Tick a pocket below to highlight it in the 3D structure above.
| Compound | APC |
| Residue | . / 3002 |
| Chain | V / B |
| Non-redundant | True |
| Interacting RNA chains | O/R |
| RNA environment detailled | DNA, protein, ion |
| RNA environment global | RNA/DNA/Protein |
| RNA family chains | O/R: rRNA |
| RNA family global | rRNA |
| Volume | 705.89 Å3 |
| Hydrophobicity | 0.681 |
| Hydrophilicity | 1.046 |
| Buriedness | 0.769 |
| Don/acc character | 1.173 |
| SiteScore | 1.047 |
| D Score | 1.060 |
| Kd | — |