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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 9f1b

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 3.01
System mass 4100.33 kDa
Deposition year 2024
Molecule type RNA/Protein
# RNA entities 1
Organism Oryctolagus
RCSB PDB Entry 9f1b
Reference Lentzsch Alfred M., Yudin Denis, Gamerdinger Martin, Chandrasekar Sowmya, Rabl Laurenz, Scaiola Alain, Deuerling Elke, Ban Nenad, Shan Shu-ou. 2024. NAC guides a ribosomal multienzyme complex for nascent protein processing Nature
Equivalence Class NR_all_21280.51, NR_all_06650.50
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound SPM
Residue . / 5018
Chain QH / B5
Non-redundant True
Interacting RNA chains X/B5
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains X/B5: rRNA
RNA family global rRNA
Volume 298.41 Å3
Hydrophobicity 0.024
Hydrophilicity 1.305
Buriedness 0.675
Don/acc character 1.488
SiteScore 0.899
D Score 0.810
Kd

Compound SPM
Residue . / 5061
Chain HJ / B5
Non-redundant True
Interacting RNA chains X/B5
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains X/B5: rRNA
RNA family global rRNA
Volume -
Hydrophobicity -
Hydrophilicity -
Buriedness -
Don/acc character -
SiteScore -
D Score -
Kd

Compound SPM
Residue . / 1994
Chain HCA / A2
Non-redundant True
Interacting RNA chains KB/A2
RNA environment detailled ion
RNA environment global RNA
RNA family chains KB/A2: rRNA
RNA family global rRNA
Volume 670.57 Å3
Hydrophobicity 0.410
Hydrophilicity 1.014
Buriedness 0.773
Don/acc character 2.440
SiteScore 1.206
D Score 1.073
Kd