Complex 9dts
Legend
Pocket colors by molecule type
RNA
Protein
DNA
These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).
System information
| Experimental technique | X-ray |
| Experimental resolution | 1.69 |
| System mass | 194.60 kDa |
| Deposition year | 2024 |
| Molecule type | RNA/Protein |
| # RNA entities | 1 |
| Organism | Homo |
| RCSB PDB Entry | 9dts |
| Reference | Conley James F., Brown Lauren E., McNeely James H., Pelletier Jerry, Porco John A., Allen Karen N.. 2025. Structural Basis for the Improved RNA Clamping of Amidino-Rocaglates to eIF4A1 ACS Omega |
| Equivalence Class |
NR_all_45897.2,
NR_all_85544.2
BGSU version: 4.52 |
Pockets List
Legend
Cell colors for SiteScore and D Score:
Favourable
Intermediate
Unfavourable
Not available
| Score | Threshold | Meaning |
|---|---|---|
| SiteScore | < 0.8 | Non-drug binding site |
| SiteScore | 0.8 – 1.0 | Potential drug binding site |
| SiteScore | > 1.0 | Promising binding site |
| D Score | < 0.83 | Undruggable |
| D Score | 0.83 – 0.98 | Difficult |
| D Score | > 0.98 | Druggable |
Tick a pocket below to highlight it in the 3D structure above.
| Compound | A1BB1 |
| Residue | . / 503 |
| Chain | Q / D |
| Non-redundant | True |
| Interacting RNA chains | H/Z |
| RNA environment detailled | protein |
| RNA environment global | RNA/Protein |
| RNA family chains | H/Z: unknown |
| RNA family global | unknown |
| Volume | 190.37 Å3 |
| Hydrophobicity | 0.802 |
| Hydrophilicity | 0.582 |
| Buriedness | 0.586 |
| Don/acc character | 1.567 |
| SiteScore | 0.788 |
| D Score | 0.813 |
| Kd | — |
| Compound | A1BB1 |
| Residue | . / 101 |
| Chain | R / W |
| Non-redundant | False |
| Interacting RNA chains | E/W |
| RNA environment detailled | protein |
| RNA environment global | RNA/Protein |
| RNA family chains | E/W: unknown |
| RNA family global | unknown |
| Volume | 236.33 Å3 |
| Hydrophobicity | 0.845 |
| Hydrophilicity | 0.775 |
| Buriedness | 0.630 |
| Don/acc character | 1.220 |
| SiteScore | 0.895 |
| D Score | 0.923 |
| Kd | — |
| Compound | A1BB1 |
| Residue | . / 101 |
| Chain | S / X |
| Non-redundant | False |
| Interacting RNA chains | F/X |
| RNA environment detailled | protein |
| RNA environment global | RNA/Protein |
| RNA family chains | F/X: unknown |
| RNA family global | unknown |
| Volume | 201.34 Å3 |
| Hydrophobicity | 0.875 |
| Hydrophilicity | 0.586 |
| Buriedness | 0.581 |
| Don/acc character | 1.299 |
| SiteScore | 0.867 |
| D Score | 0.915 |
| Kd | — |
| Compound | A1BB1 |
| Residue | . / 101 |
| Chain | T / Y |
| Non-redundant | False |
| Interacting RNA chains | G/Y |
| RNA environment detailled | protein |
| RNA environment global | RNA/Protein |
| RNA family chains | G/Y: unknown |
| RNA family global | unknown |
| Volume | 250.05 Å3 |
| Hydrophobicity | 0.767 |
| Hydrophilicity | 0.842 |
| Buriedness | 0.597 |
| Don/acc character | 1.309 |
| SiteScore | 0.949 |
| D Score | 0.995 |
| Kd | — |