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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 9did

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Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique X-ray
Experimental resolution 2.80
System mass 75.84 kDa
Deposition year 2024
Molecule type RNA
# RNA entities 1
Organism Alpharetrovirus
RCSB PDB Entry 9did
Reference Jones Christopher P., Ferré-D’Amaré Adrian R.. 2025. Structural switching dynamically controls the doubly pseudoknotted Rous sarcoma virus–programmed ribosomal frameshifting element Proceedings of the National Academy of Sciences
Equivalence Class NR_all_12146.2
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound TAM
Residue . / 209
Chain K / A
Non-redundant True
Interacting RNA chains A/A
RNA environment detailled ion
RNA environment global RNA
RNA family chains A/A: unknown
RNA family global unknown
Volume 399.94 Å3
Hydrophobicity 0.037
Hydrophilicity 1.123
Buriedness 0.725
Don/acc character 1.384
SiteScore 0.932
D Score 0.706
Kd