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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 9cai

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 2.59
System mass 3163.65 kDa
Deposition year 2024
Molecule type RNA/Protein
# RNA entities 1
Organism Caenorhabditis
RCSB PDB Entry 9cai
Reference Sehgal Enisha, Wohlenberg Chloe, Soukup Evan M., Viscardi Marcus J., Serrão Vitor Hugo Balasco, Arribere Joshua A.. 2024. High-resolution reconstruction of aC. elegansribosome sheds light on evolutionary dynamics and tissue specificity RNA
Equivalence Class NR_all_54953.3
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound 3HE
Residue . / 3602
Chain CC / A5
Non-redundant True
Interacting RNA chains L/A5
RNA environment detailled protein, other
RNA environment global RNA/Other
RNA family chains L/A5: rRNA
RNA family global rRNA
Volume 332.37 Å3
Hydrophobicity 0.510
Hydrophilicity 0.977
Buriedness 0.673
Don/acc character 0.930
SiteScore 0.996
D Score 1.025
Kd