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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 9c4g

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 2.53
System mass 1448.52 kDa
Deposition year 2024
Molecule type RNA/Protein
# RNA entities 1
Organism Cutibacterium
RCSB PDB Entry 9c4g
Reference Lomakin Ivan B., Devarkar Swapnil C., Grada Ayman, Bunick Christopher G.. 2024. Mechanistic Basis for the Translation Inhibition of Cutibacterium acnes by Clindamycin Journal of Investigative Dermatology
Equivalence Class NR_all_00194.1
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound CLY
Residue . / 3342
Chain TJ / a
Non-redundant True
Interacting RNA chains BA/a
RNA environment detailled ion
RNA environment global RNA
RNA family chains BA/a: rRNA
RNA family global rRNA
Volume 742.60 Å3
Hydrophobicity 0.421
Hydrophilicity 1.188
Buriedness 0.767
Don/acc character 1.364
SiteScore 1.196
D Score 1.013
Kd