Complex 8xpo
Legend
Pocket colors by molecule type
RNA
Protein
DNA
These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).
System information
| Experimental technique | Electron Microscopy |
| Experimental resolution | 3.02 |
| System mass | 273.53 kDa |
| Deposition year | 2024 |
| Molecule type | RNA/Protein |
| # RNA entities | 1 |
| Organism | N/A |
| RCSB PDB Entry | 8xpo |
| Reference | Jia Xiaoying, Jing Xuping, Li Ming, Gao Minli, Zhong Yao, Li Entao, Liu Yang, Li Rui, Yao Guoqiang, Liu Qiaojie, Zhou Minmin, Hou Yuxia, An Linfeng, Hong Yibao, Li Shanshan, Zhang Jiancun, Wang Wei, Zhang Kaiming, Gong Peng, Chiu Sandra. 2024. An adenosine analog shows high antiviral potency against coronavirus and arenavirus mainly through an unusual base pairing mode Nature Communications |
| Equivalence Class |
NR_all_62308.1
BGSU version: 4.52 |
Pockets List
Legend
Cell colors for SiteScore and D Score:
Favourable
Intermediate
Unfavourable
Not available
| Score | Threshold | Meaning |
|---|---|---|
| SiteScore | < 0.8 | Non-drug binding site |
| SiteScore | 0.8 – 1.0 | Potential drug binding site |
| SiteScore | > 1.0 | Promising binding site |
| D Score | < 0.83 | Undruggable |
| D Score | 0.83 – 0.98 | Difficult |
| D Score | > 0.98 | Druggable |
Tick a pocket below to highlight it in the 3D structure above.
| Compound | A1LVZ |
| Residue | . / 2401 |
| Chain | E / L |
| Non-redundant | True |
| Interacting RNA chains | D/P, C/T |
| RNA environment detailled | protein |
| RNA environment global | RNA/Protein |
| RNA family chains | C/T: synthetic construct, D/P: synthetic construct |
| RNA family global | synthetic construct |
| Volume | 684.63 Å3 |
| Hydrophobicity | 0.399 |
| Hydrophilicity | 1.364 |
| Buriedness | 0.834 |
| Don/acc character | 0.638 |
| SiteScore | 1.091 |
| D Score | 0.996 |
| Kd | — |