Complex 8vxz
Legend
Pocket colors by molecule type
RNA
Protein
DNA
These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).
System information
| Experimental technique | X-ray |
| Experimental resolution | 3.00 |
| System mass | 37.44 kDa |
| Deposition year | 2024 |
| Molecule type | RNA |
| # RNA entities | 1 |
| Organism | N/A |
| RCSB PDB Entry | 8vxz |
| Reference | Yang Mo, Prestwood Peri R., Passalacqua Luiz F. M., Balaratnam Sumirtha, Fullenkamp Christopher R., Arney J. Winston, Weeks Kevin M., Ferre-D’Amare Adrian, Schneekloth John S.. 2025. Structure-informed design of an ultrabright RNA-activated fluorophore Nature Chemistry |
| Equivalence Class |
NR_all_82829.3
BGSU version: 4.52 |
Pockets List
Legend
Cell colors for SiteScore and D Score:
Favourable
Intermediate
Unfavourable
Not available
| Score | Threshold | Meaning |
|---|---|---|
| SiteScore | < 0.8 | Non-drug binding site |
| SiteScore | 0.8 – 1.0 | Potential drug binding site |
| SiteScore | > 1.0 | Promising binding site |
| D Score | < 0.83 | Undruggable |
| D Score | 0.83 – 0.98 | Difficult |
| D Score | > 0.98 | Druggable |
Tick a pocket below to highlight it in the 3D structure above.
| Compound | A1AED |
| Residue | . / 104 |
| Chain | G / A |
| Non-redundant | True |
| Interacting RNA chains | A/A |
| RNA environment detailled | ion |
| RNA environment global | RNA |
| RNA family chains | A/A: aptamer_rna |
| RNA family global | aptamer_rna |
| Volume | 402.00 Å3 |
| Hydrophobicity | 0.717 |
| Hydrophilicity | 0.695 |
| Buriedness | 0.643 |
| Don/acc character | 2.820 |
| SiteScore | 1.180 |
| D Score | 1.099 |
| Kd | — |
| Compound | A1AED |
| Residue | . / 103 |
| Chain | J / B |
| Non-redundant | False |
| Interacting RNA chains | B/B |
| RNA environment detailled | ion |
| RNA environment global | RNA |
| RNA family chains | B/B: aptamer_rna |
| RNA family global | aptamer_rna |
| Volume | 351.92 Å3 |
| Hydrophobicity | 0.640 |
| Hydrophilicity | 0.723 |
| Buriedness | 0.606 |
| Don/acc character | 3.856 |
| SiteScore | 1.149 |
| D Score | 1.068 |
| Kd | — |
| Compound | A1AED |
| Residue | . / 104 |
| Chain | N / C |
| Non-redundant | False |
| Interacting RNA chains | C/C |
| RNA environment detailled | ion |
| RNA environment global | RNA |
| RNA family chains | C/C: aptamer_rna |
| RNA family global | aptamer_rna |
| Volume | - |
| Hydrophobicity | - |
| Hydrophilicity | - |
| Buriedness | - |
| Don/acc character | - |
| SiteScore | - |
| D Score | - |
| Kd | — |